Syrian state media said that Israel had carried out an air raid on Wednesday in a region near the border with Lebanon which is a known stronghold of Hezbollah.
A leading monitor said that 15 people had been killed in the strikes although there was no immediate confirmation from Syrian authorities.
The Sana news agency said that "the Israeli aggression" on the Homs region had been met with a barrage of anti-aircraft fire.
Citing a military source, Sana said that the Israeli planes had targeted bridges along the Orontes river and roads around the Syria-Lebanon border.
The Israeli army stated that it had targeted routes Hezbollah uses to smuggle weapons from Syria into Lebanon.
The strikes had caused "significant damage", putting some of the infrastructure out of action, according to the source, who did not provide details.
The Syrian Observatory for Human Rights war monitor also said that Israeli military aircraft had hit Syrian bridges and military checkpoints.
Fifteen members of the Syrian armed forces or allied groups had been killed in the strikes, said the observatory, which has a vast network of contacts throughout Syria.
Israel rarely comments on its military operations in Syria.
But since civil war broke out in Syria in 2011, it has carried out hundreds of air strikes on Syrian government forces and groups supported by its arch-foe Iran, notably Hezbollah troops that have been deployed to assist Assad's regime.
Israel has carried out frequent raids on highways on the Lebanese side of the border with Syria to cut off potential weapons supplies since a major escalation of its conflict with Hezbollah in September.
With AFP
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